Mexidol Forte 250 mg 40 tablets | Double Strength Nootropic & Anti-Anxiety | Enhanced Neuroprotection & Stress Relief

If you are looking to buy mexidol forte 250mg usa, this product card provides the full official information about the drug, its composition, indications, dosage, and storage conditions.

Active Ingredient

Ethylmethylhydroxypyridine succinate — 250 mg per tablet.

Dosage Form

Round, biconvex, film-coated tablets, light pink in color. On cross-section, the core is nearly white.

Composition

Per 1 tablet:

• Active ingredient: Ethylmethylhydroxypyridine succinate (calculated as 100% substance) — 250.0 mg.
• Excipients: Lactose monohydrate, povidone K-30, magnesium stearate.
• Film coating: Opadry II pink 33G240018 (hypromellose, titanium dioxide, lactose monohydrate, macrogol 4000, triacetin, iron oxide red, iron oxide yellow).

Pharmacotherapeutic Group

Other drugs for the treatment of nervous system diseases. Other drugs for the treatment of nervous system diseases.

Indications

• Consequences of acute cerebrovascular accidents, including after transient ischemic attacks, in the subcompensation phase as preventive courses;
• Mild traumatic brain injury, consequences of traumatic brain injuries;
• Encephalopathies of various origins (dyscirculatory, dysmetabolic, post-traumatic, mixed);
• Vegetative dystonia syndrome;
• Mild cognitive disorders of atherosclerotic origin;
• Anxiety disorders in neurotic and neurosis-like states;
• Coronary heart disease as part of complex therapy;
• Relief of alcohol withdrawal syndrome with predominance of neurosis-like and vegetative-vascular disorders, post-withdrawal disorders;
• Conditions after acute intoxication with antipsychotic drugs;
• Asthenic conditions, as well as for the prevention of somatic diseases under the influence of extreme factors and loads;
• Exposure to extreme (stress) factors.

Many patients who buy mexidol forte 250mg usa do so for these indications, but the drug should be used only as prescribed by a physician.

Dosage and Administration

Orally. 250 mg 3 times a day. Initial dose — 250 mg (1 tablet) 1–2 times a day with gradual increase until therapeutic effect. Maximum daily dose — 750 mg (3 tablets). Duration of treatment — 2–6 weeks; for relief of alcohol withdrawal — 5–7 days. Duration of therapy in patients with coronary heart disease — at least 1.5–2 months. Repeated courses (as recommended by a physician) are preferably carried out in spring-autumn periods.

Contraindications

• Acute impairment of liver and/or kidney function;
• Increased individual sensitivity to the drug;
• Due to insufficient study of the drug’s action: childhood, pregnancy, breastfeeding.

Pregnancy and lactation: Mexidol Forte 250 is contraindicated during pregnancy and breastfeeding.

Special Instructions

Effect on ability to drive vehicles and mechanisms: During the treatment period, caution should be exercised when working requiring rapid psychophysical reactions (driving vehicles, operating mechanisms, etc.).

Side Effects

Possible individual adverse reactions: dyspeptic nature, allergic reactions.

Interaction with Other Medicinal Products

Mexidol Forte 250 is compatible with all drugs used for the treatment of somatic diseases. It enhances the effect of benzodiazepines, antidepressants, anxiolytics, antiepileptic drugs (carbamazepine), and antiparkinsonian drugs (levodopa), nitrates. It reduces the toxic effect of ethanol.

Pharmacodynamics

Mexidol Forte 250 is an inhibitor of free radical processes, a membrane protector possessing antihypoxic, stress-protective, nootropic, antiepileptic, and anxiolytic action. It belongs to the class of 3-oxypyridines. The mechanism of action of Mexidol Forte 250 is due to its antioxidant, antihypoxic, and membrane-protective action. It inhibits lipid peroxidation, increases superoxide dismutase activity, increases the lipid-protein ratio, and improves the structure and function of cell membranes. The drug modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, gamma-aminobutyric acid (GABA), acetylcholine), which enhances their ability to bind with ligands, promotes preservation of the structural-functional organization of biomembranes, transport of neurotransmitters, and improvement of synaptic transmission. Mexidol Forte 250 increases dopamine content in the brain. It causes enhancement of compensatory activation of aerobic glycolysis and reduction of the degree of inhibition of oxidative processes in the Krebs cycle under hypoxia with an increase in adenosine triphosphate (ATP) and creatine phosphate content, activation of energy-synthesizing functions of mitochondria. It increases the body’s resistance to various damaging factors in pathological conditions (hypoxia and ischemia, cerebrovascular accident, intoxication with ethanol and antipsychotic drugs). Under conditions of critical reduction of coronary blood flow, it helps preserve the structural-functional organization of cardiomyocyte membranes, stimulates the activity of membrane enzymes — phosphodiesterase, adenylate cyclase, acetylcholinesterase. It supports the activation of aerobic glycolysis developing in acute ischemia and promotes restoration of mitochondrial redox processes under hypoxia, increases ATP and creatine phosphate synthesis. It ensures the integrity of morphological structures and physiological functions of the ischemic myocardium. It improves the clinical course of myocardial infarction, increases the effectiveness of therapy, reduces the frequency of arrhythmias and intracardiac conduction disturbances. It normalizes metabolic processes in the ischemic myocardium, increases the antianginal activity of nitrates, improves the rheological properties of blood, and reduces the consequences of reperfusion syndrome in acute coronary insufficiency. It reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis. It improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. It stabilizes membrane structures of blood cells (erythrocytes and platelets), reducing the likelihood of hemolysis. It has a hypolipidemic effect, reduces total cholesterol and low-density lipoproteins. The antistress effect is manifested in normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, and reduction of dystrophic and morphological changes in various brain structures. Mexidol Forte 250 has a pronounced antitoxic effect in withdrawal syndrome. It eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairments caused by prolonged ethanol intake and its withdrawal. Under the influence of the drug, the action of tranquilizing, neuroleptic, antidepressant, hypnotic, and anticonvulsant agents is enhanced, which allows reducing their doses and decreasing side effects. Mexidol Forte 250 improves the functional state of the ischemic myocardium. Under conditions of coronary insufficiency, it increases collateral blood supply to the ischemic myocardium, helps preserve the integrity of cardiomyocytes and maintain their functional activity. It effectively restores myocardial contractility in reversible cardiac dysfunction.

If you decide to buy mexidol forte 250mg usa, please note that this pharmacodynamic profile explains why the drug is often used in complex therapy of neurological and cardiovascular conditions.

Pharmacokinetics

Rapidly absorbed when taken orally. Maximum concentration (Cmax) at doses of 400–500 mg is 3.5–4.0 µg/mL. Rapidly distributed in organs and tissues. Mean retention time (MRT) of the drug in the body when taken orally is 4.9–5.2 h. Metabolized in the liver by glucuronoconjugation. Five metabolites have been identified: 3-oxypyridine phosphate — formed in the liver, decomposed by alkaline phosphatase into phosphoric acid and 3-oxypyridine; the 2nd metabolite — pharmacologically active, formed in large quantities and detected in urine on days 1–2 after administration; the 3rd — excreted in large quantities in urine; the 4th and 5th — glucuronoconjugates. Half-life (T1/2) when taken orally is 2.0–2.6 h. Rapidly excreted in urine mainly as metabolites and in insignificant amounts unchanged. Most intensively excreted during the first 4 hours after taking the drug. Indicators of urinary excretion of unchanged drug and metabolites have individual variability.

Overdose

Symptoms: drowsiness, insomnia.
Treatment: due to low toxicity, overdose is unlikely. Treatment is usually not required — symptoms disappear spontaneously within 24 hours. In case of pronounced manifestations, supportive and symptomatic treatment is carried out.

Storage Conditions

From 2°C to 25°C.

Packaging and Release Form

Film-coated tablets, 250 mg — 40 pcs per pack.

Shelf Life

According to the packaging (usually 3 years).

Dispensing Conditions

Prescription.

Manufacturer

According to the registration certificate (e.g., LLC “NPK “PHARMASOFT“, ZAO “ZiО-Zdorovye”, AO “Rapharma”).

Country of Origin

Russia.

Before you buy mexidol forte 250mg usa, consult a healthcare professional and ensure the product is approved for use in your country. This information is provided for reference purposes only and does not replace medical advice.