- Product name: Mildronate 500mg, 60 capsules
- Expiry: Dec 2029
- EAN: 4750232006603
- Active ingredient: Meldonium dihydrate — 500 mg per capsule
- Dosage form: Hard gelatin capsules, 60 count
- Manufacturer: Grindex (Grindeks JSC)
- Country of manufacture: Latvia
Directions:
Capsules are taken orally. Dosing is recommended in the first half of the day; the last dose should be no later than 5:00 p.m. The regimen must be selected by your attending physician.
– Ischemic heart disease and chronic heart failure: 500 mg–1 g daily, once or divided into two doses, for 4–6 weeks.
– Ischemic heart disease and chronic heart failure: 500 mg–1 g daily, once or divided into two doses, for 4–6 weeks.
– Dyshormonal cardiomyopathy: 500 mg once daily for 12 days.
– Cerebral blood supply disorders: after injectable Mildronate, 500 mg–1 g orally daily for 4–6 weeks; chronic cases: 500 mg daily for 4–6 weeks.
– Reduced performance or overload: adults 500 mg twice daily for 10–14 days; repeat after 2–3 weeks if needed.
– Athletes: 500 mg–1 g twice daily before training; 14–21 days preparation, 10–14 days competition.
– Alcohol-withdrawal syndrome: with specific therapy, 500 mg four times daily for 7–10 days.
When you buy Mildronate 500mg online shipping USA, do not change dose or duration without consulting your attending physician. Composition: Each capsule contains 500 mg meldonium dihydrate. Excipients: potato starch, silicon dioxide, calcium stearate. Capsule: titanium dioxide (E171), gelatin.
Contraindications: Hypersensitivity; increased intracranial pressure; age under 18; pregnancy; breastfeeding. Caution in liver/kidney disease. Safety in pregnancy is not established; discontinue breastfeeding if treatment is necessary. Strict consultation with your attending physician is required.
Warnings: Chronic liver or kidney disease requires caution and medical supervision. Insufficient data for children under 18. No data indicate effects on driving or machinery. If you buy mildronate 500mg online shipping USA, confirm personal use under strict medical consultation and comply with local import rules.
Adverse effects: When you buy mildronate 500mg online shipping USA, Rarely allergy-related skin reactions, dyspepsia, tachycardia, blood pressure changes, increased excitability; very rarely eosinophilia and weakness. Seek medical advice for severe reactions especially when you buy mildronate 500mg online shipping USA.
Interactions: May enhance coronary vasodilators, some antihypertensives, and cardiac glycosides. Caution with sublingual nitroglycerin, alpha-blockers, and short-acting nifedipine. If you want to buy mildronate 500mg online shipping USA , Tell your attending physician about all medicines.
Pharmacodynamics and pharmacokinetics: Meldonium is a synthetic gamma-butyrobetaine analogue. It inhibits gamma-butyrobetaine hydroxylase, reduces carnitine synthesis and long-chain fatty acid transport, and limits accumulation of unoxidized fatty acid derivatives. Under ischemia, this helps balance oxygen delivery and demand, supports ATP transport, and activates glycolysis without extra oxygen. Oral bioavailability is 78%; peak plasma concentration in 1–2 hours; half-life 3–6 hours. It is metabolized in the liver and excreted by the kidneys.
Storage: Store at 2–25 °C (36–77 °F). Keep out of reach of children. No. 00 hard gelatin capsules, white body and cap; contents are a white, hygroscopic crystalline powder with slight odor. Aptechka.store ships the 60-capsule pack.
Overdose: Possible decreased blood pressure, headache, tachycardia, dizziness, weakness. Treatment is symptomatic. Seek medical attention if overdose is suspected. Consult with your doctor before you buy mildronate 500mg online shipping USA.
References:
- «Grindeks: We Believe that Meldonium Should not be Included in the List of Banned Substances in Sport». Grindeks. 9 March 2016. Archived from the original on 12 March 2016. Retrieved 9 March 2016.
- Liepnich et al (2009) Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats
- Liepnich et al (2009) Effects of long-term mildronate treatment on cardiac and liver functions in rats
- Trumbeckaite et al (2009) Effects of ischemia-reperfusion and pretreatment with mildronate on rat liver mitochondrial function
- Vilskersts et al (2009) Mildronate, a Regulator of Energy Metabolism, Reduces Atherosclerosis in apoE/LDLR –/– Mice
- Jaudzems et al (2009) Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism
- Zvejniece et al (2010) Mildronate exerts acute anticonvulsant and antihypnotic effects
- Kuka et al (2011) The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine
- Isajevs et al (2011) Mildronate as a Regulator of Protein Expression in a Rat Model of Parkinson’s Disease
- V. Dzerve (2011) A Dose-Dependent Improvement in Exercise Tolerance in Patients With Stable Angina Treated With Mildronate: A Clinical Trial “MILSS I”
- Zhu et al (2013) Efficacy and Safety of Mildronate for Acute Ischemic Stroke: A Randomized, Double-Blind, Active-Controlled Phase II Multicenter Trial
- Klusa et al (2013) Mildronate and its Neuroregulatory Mechanisms: Targeting the Mitochondria, Neuroinflammation, and Protein Expression
- Klusa et al (2013) Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats
- Beitnere et al (2014) Carnitine congener mildronate protects against stress and haloperidol-induced impairment in memory and brain protein expression in rats
- Zhao et al (2015) Single- and Multiple-dose Pharmacokinetic, Safety and Tolerability Study of Mildronate Injection in Healthy Chinese Subjects Pharmacokinetic of Mildronate Injection
- Dambrova et al (2016) Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity
- Schobersberger et al (2016) Story behind meldonium-from pharmacology to performance enhancement: a narrative review
- Di Cristo et al (2019) Meldonium improves Huntington’s disease mitochondrial dysfunction by restoring peroxisome proliferator-activated receptor γ coactivator 1α expression
- Gureev et al (2021) Mildronate protects heart mtDNA from oxidative stress toxicity induced by exhaustive physical exercise
- Savic et al (2021) Hyperpolarized magnetic resonance shows that the anti-ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post-ischemic function in the diabetic heart
- «Experts say there’s little evidence meldonium enhances performance». USA Today. Retrieved 8 April
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